Response:

We thank Drs Ayubi and Safiri1 for their interest in the statistics of our study on the efficacy and safety of endoscopic submucosal tunnel (ESD) dissection for superficial esophageal squamous cell carcinoma. In regression analysis, specimen size did show a large confidence interval, possibly because of the small sample size of the study. We agree that there is potential doubt about the significance of this factor.

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