PBP4 mediates {beta}-lactam resistance by altered function [PublishAheadOfPrint]

Penicillin Binding Protein 4 (PBP4) can provide high-level β-lactam resistance in S. aureus. A series of missense and promoter mutations associated with pbp4 were detected in strains that displayed high-level resistance. We hereby show that the missense mutations facilitate the β-lactam resistance mediated by PBP4 and the promoter mutations lead to the overexpression of pbp4. Our results also suggest a co-operative interplay between PBPs for β-lactam resistance.

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