High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma

Abstract

High molecular weight caldesmon (H-caldesmon) is the protein that binds to actin and tropomyosin regulating smooth muscle contraction function.¹ It is mainly expressed in smooth muscle cells and the research data showed the specificity of smooth muscle is higher than that of desmin and actin.² In clinical diagnosis, H-caldesmon can be used to identify myofibroblastic tumors from true leiomyoma and to differentiate uterine smooth muscle tumors from endometrial stromal sarcoma combined with CD10. Resently, we encountered a case of ovarian adult granulosa cell tumor.

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