Hard Spheres with Purely Repulsive Interactions Have Positive Diffusion Interaction Parameter, kD

Sorret et al. (1) recently critically discussed our paper in Biophysical Journal (2,3) where we emphasized the need to consider the macromolecular nature of proteins when considering their structure over a large range of protein concentration (c), pH, etc. In particular, they criticized our interpretation of pH-dependent measurements of Bovine Serum Albumin (BSA) Stokes radius using Dynamic Light Scattering (DLS) (4), and independent intrinsic viscosity [η] measurements (5), as implying a change in conformation when pH is varied.

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