Construction of Silica-Based Micro/Nanoplatforms for Ultrasound Theranostic Biomedicine

Ultrasound (US)-based biomedicine has been extensively explored for its applications in both diagnostic imaging and disease therapy. The fast development of theranostic nanomedicine significantly promotes the development of US-based biomedicine. This progress report summarizes and discusses the recent developments of rational design and fabrication of silica-based micro/nanoparticles for versatile US-based biomedical applications. The synthetic strategies and surface-engineering approaches of silica-based micro/nanoparticles are initially discussed, followed by detailed introduction on their US-based theranostic applications. They have been extensively explored in contrast-enhanced US imaging, US-based multi-modality imaging, synergistic high-intensity focused US (HIFU) ablation, sonosensitizer-enhanced sonodynamic therapy (SDT), as well as US-triggered chemotherapy. Their biological effects and biosafety have been briefly discussed to guarantee further clinical translation. Based on the high biocompatibility, versatile composition/structure and high performance in US-based theranostic biomedicine, these silica-based theranostic agents are expected to pave a new way for achieving efficient US-based theranostics of disease by taking the specific advantages of material science, nanotechnology and US-based biomedicine.

Recent development of the design and fabrication of silica-based micro/nanoparticles for versatile ultrasound (US)-based biomedical applications is summarized and discussed in this Progress Report. Synthetic strategies and surface-engineering approaches of silica-based micro/nanoparticles are initially discussed, followed by the comprehensive introduction on their broad applications in US-based theranostics. These silica-based micro/nanoparticles have been extensively explored in contrast-enhanced diagnostic US imaging, US-based multi-modality imaging, synergistic high-intensity focused ultrasound (HIFU) ablation, sonosensitizer-enhanced sonodynamic therapy (SDT), as well as US-triggered on-demand chemotherapy. The specific biological effects and biosafety of these silica-based micro/nanoparticles have been briefly discussed to guarantee their further clinical translation.

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