Precarious maintenance of simple DNA repeats in eukaryotes:In article number 1700077, Sergei M. Mirkin and co-workers present a model for replication fork uncoupling at expandable (GAA)n repeats responsible for Friedreich's ataxia. Lagging strand synthesis by DNA polymerase δ (blue oval) is stalled when the repetitive 5‵-flap of an Okazaki fragment (green strand) folds forward forming a triplex with the downstream duplex. This may prompt Pol δ to switch templates to the nascent leading strand, resulting in repeat expansions.
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