What Elements Suggest Infectious Mononucleosis?

Authors screened 670 abstracts and selected 117 for full-text review, of which 11 met inclusion criteria. A total of 4,769 patients were included, of whom 2,345 had serologically confirmed mononucleosis. Three studies were prospective cohort studies, 3 were retrospective laboratory studies without clinical information, and 5 were case series with confirmed mononucleosis. Of the studied elements, atypical lymphocytes had the greatest positive LR (Table). None of the examined elements were sufficient to exclude the diagnosis.

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