Reduced Functional Connectivity between Ventromedial Prefrontal Cortex and Insula Relates to Longer Corrected QT Interval in HIV+ and HIV- Individuals

Despite the widespread availability of antiretroviral therapy, mortality from cardiovascular disease (CVD) has increased for persons infected with human immunodeficiency virus (HIV) (Enakpene et al., 2015). A large proportion of this CVD comorbidity has been attributed to sudden cardiac death (Tseng et al., 2012). The QT interval reflects the latency between the initiation of the QRS-complex and end of the T-wave and is used as a general marker of ventricular repolarization (Drew et al., 2010). Clinical presentation of ventricular arrhythmias (i.e., torsade de pointes) is partially attributed to prolongation of the QT interval (Viskin, 1999).

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