A prospective randomized study of radiation dose escalation with combined proton-photon therapy for benign meningiomas

Fractionated radiotherapy is commonly used to treat recurrent or subtotally resected benign meningiomas (BM). This randomized controlled trial evaluates the role of dose escalation for BM and does not support a benefit with higher radiation dose within the dose range evaluated of 55.8 Gy(RBE) vs. 63 Gy(RBE). Twenty percent of the cohort incurred a cerebrovascular accident, emphasizing the importance of long-term surveillance for late toxicities.

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