The Esophageal Epithelial Barrier in Health and Disease

Dysfunction in the esophageal epithelial barrier function is a major source for morbidity. In order to better understand the pathophysiologic pathways of the diseases associated with barrier dysfunction, including gastroesophageal reflux disease (GERD), eosinophilic esophagitis (EoE), Barrett's esophagus (BE) and obesity, it is important to understand the esophageal epithelial embryologic development, microscopic anatomy with a special focus on the barrier structure and function, extra-epithelial defense mechanisms and how these change in the diseased state.

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