Response to the Letter to the Editor

Abstract

We appreciate the insights and concerns raised in the above letter to the editor. The authors have thoughtfully highlighted some important distinctions between the original derivation of NOTR and our validation study.^1,2 Specifically, the original NOTR derivation included cardiac death, acute myocardial infarction (MI), unstable angina (UA), and "urgent and emergent" revascularization in a composite safety endpoint (and did not include "elective" coronary revascularizations). Our study included death, MI, and any coronary revascularization events, but did not include UA.

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