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In our recent study, "Efficacy of Intravenous and Endotracheal Epinephrine during Neonatal Cardiopulmonary Resuscitation in the Delivery Room,"1 we raise concerns that the currently recommended dosing recommendations for both intravenous and endotracheal (ET) epinephrine frequently needed to be repeated before return of spontaneous circulation (ROSC) is achieved. We also demonstrated that the vast majority of infants who achieved ROSC did so after receiving an intravenous (IV) dose of epinephrine even if prior ET doses were provided.

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