Lymphocyte Nadir and Esophageal Cancer Survival Outcomes Following Chemoradiotherapy

We evaluated whether decreased host immunity, as seen by lymphopenia, during chemoradiation for esophageal cancer affect survival and if so, are there factors that may predict for lymphopenia. In this retrospective study that included 504 patients, lymphopenia was significantly associated with poor patient outcomes. Chemo regimen, radiation modality, tumor location, and mean body dose predicted for lymphopenia.

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