Comparison of two phenotypic algorithms to detect carbapenemase-producing Enterobacteriaceae [PublishAheadOfPrint]

A novel algorithm designed for the screening of carbapenemase producing Enterobactericeae (CPE), based on faropenem and temocillin disks was compared to that of the French Society of Microbiology (CA-SFM), which is based on ticarcillin-clavulanate, imipenem and temocillin disks. Both algorithms presented comparable negative predictive values (98.6% vs 97.5%) for the CPE screening among carbapenem non-susceptible Enterobacteriaceae. However, since 46.2% (n=49) of the CPEs were correctly identified as OXA-48-like producers by the faropenem/temocillin-based algorithm, it significantly decreased the number of complementary tests needed (42.2% vs 62.6% with the CA-SFM algorithm).

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