HLA Matching in Pediatric Kidney Transplantation: HLA Poorly Matched Living Donor Transplants Versus HLA Well Matched Deceased Donor Transplants.

Background: Based on an analysis of 542 pediatric kidney transplants recorded by the UK Transplant Registry from 2000-2012, it was concluded that the survival rate of HLA poorly matched living donor transplants is not inferior to that of HLA well matched deceased donor transplants. Methods: We analyzed the impact of HLA matching on kidney graft survival in 3627 pediatric living donor transplants performed during 2000-2015 using the data of the Collaborative Transplant Study. The impact of HLA mismatches on graft survival was analyzed and survival rates of transplants from poorly matched living donors were compared to those from well matched deceased donors. Multivariate Cox regression analysis was used to account for the influence of confounders. Results: HLA matching had a statistically significant impact on graft survival of pediatric kidney transplants (P

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