A Novel Scheme for the Validation of an Automated Classification Method for Epileptic Spikes by Comparison with Multiple Observers

As part of standard practice for assessing patients with epilepsy, clinical neurophysiologists are able to detect interictal epileptiform discharges (IED or 'epileptic spikes') during interictal EEG recordings. Although there is no gold standard as to what constitutes an epileptic spike, they tend to comprise a high amplitude deflection event lasting approximately 40-100ms (De Curtis and Avanzani 2001). Some patients evaluated for resective surgical treatment for epilepsy are investigated with intracranial EEG (icEEG) usually when there is strong evidence of an epileptogenic focus but not sufficient information to define a surgically resectable area using non-invasive methods.

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