4-Substituted Thieno[2,3-d]pyrimidines as Potent Antibacterial Agents: Rational Design, Microwave-Assisted Synthesis, Biological Evaluation and Molecular Docking Studies

Abstract

In an attempt to discover a new class of antibacterial agents with improved efficacy and to overcome the drug resistant problems, some novel 4-substituted thieno[2,3-d]pyrimidines have been synthesized via microwave assisted methodology and evaluated for their in vitro antibacterial activity against various pathogenic bacterial strains. Compounds 12b and 13c showed the promising inhibitory potencies against S. aureus, B. subtilis, P. aeruginosa and E. coli with MICs ranging from 2 to 10 μg/ml. Compound 13c was also found to be highly potent against methicillin resistant S. aureus (MRSA) with MIC value of 4 μg/ml. Docking simulation studies have been performed to unravel the mode of action and association study indicate the binding of potent compounds with DHPS enzyme. In silico ADME studies suggest the drug like characteristics of the potent compounds.

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We have designed, synthesised, and evaluated the pyrimidine based compounds (1a-1d) for their potential to exhibit anti-EGFR kinase activity at nanomolar range and anticancer activity at low micromolar range.

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