What Is the Best Approach to Avoid Colorectal Cancer Risk in Inflammatory Bowel Disease?

Abstract

Inflammatory bowel diseases (IBD) comprise ulcerative colitis and Crohn's disease that primarily affect the colon and small intestine. IBD patients have a higher incidence of colorectal cancer (CRC) than the general population due to chronic colonic mucosal inflammation that predisposes to the development of dysplasia, the earliest form of neoplastic change in IBD and other chronic inflammatory disorders (e.g., Barrett's esophagus). Therefore, the two demonstrated means of reducing the risk of cancer in IBD are to control inflammation and to survey for dysplasia and remove the dysplastic area, if possible.

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