Background. CD8+ T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8+ T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well conducted. Methods. The whole Tc subsets, including Tc1/2/10/17, CD8+ regulatory T cells (Tregs) and CD8+α7+ T cells, were quantified by flow cytometry in peripheral blood from 24 stable COPD subjects (SCOPD), 14 patients during acute exacerbations (AECOPD), and 14 healthy nonsmokers (HN). Results. Acute exacerbations of COPD were accompanied by elevated levels of circulating CD8+ T cells. Tc1 cells were increased in both SCOPD and AECOPD patients, whereas the percentage of Tc2 cells was decreased in SCOPD patients but remained normal in AECOPD patients. Tc17 cells were increased only in AECOPD patients, and the percentage of Tc10 cells was reduced in both SCOPD and AECOPD patients. The imbalances of pro/anti-inflammatory Tc subsets observed in COPD may be caused by the lack of Tc10 cells and the impaired anti-inflammatory capacity of CD8+ Tregs. Conclusions. The imbalances between subsets of CD8+ peripheral blood T cells contribute to the immune response dysfunction in COPD pathogenesis.
http://ift.tt/2au72tU
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Αυγούστου
(935)
-
▼
Αυγ 02
(44)
- Supraclavicular Brown Adipose Tissue 18F-FDG Uptak...
- 2016 Cassen Prize Awarded to Strauss
- 89Zr-Bevacizumab PET Visualizes Disease Manifestat...
- McDougall Receives 2016 de Hevesy Award
- 18F-Fluoroestradiol PET: Current Status and Potent...
- Conti Recognized with Aebersold Award
- Biomarkers for Radiation Pneumonitis Using Noninva...
- ODonoghue Recognized with Loevinger-Berman Award
- Nuclear Cardiac Imaging: Principles and Applications
- Current Screening Methods Miss Worrisome Number of...
- Materials, Vol. 9, Pages 650: Inkjet-Printed Organ...
- Molecules, Vol. 21, Pages 998: Agavins Increase Ne...
- Molecules, Vol. 21, Pages 1006: Microfluidic Devic...
- Materials, Vol. 9, Pages 649: The Sulphur Poisonin...
- Life, Vol. 6, Pages 29: A Hypothesis: Life Initiat...
- Molecules, Vol. 21, Pages 997: Potential Applicati...
- Shaping emotion regulation: attunement, symptomato...
- Sensors, Vol. 16, Pages 1213: Sine Rotation Vector...
- Nutrients, Vol. 8, Pages 477: The Effect of Holder...
- Diversity, Vol. 8, Pages 17: Australian Tropical M...
- Competition and fixation of cohorts of adaptive mu...
- Imbalance between subsets of CD8+ peripheral blood...
- Bone lesions in Chinese POEMS syndrome patients: i...
- Effects of salinity change on two superoxide dismu...
- Microbial production and characterization of poly-...
- Stable isotopes in bivalves as indicators of nutri...
- The physiological consequences of varied heat expo...
- Decoupling the response of an estuarine shrimp to ...
- A framework for smartphone-enabled, patient-genera...
- The masquerade game: marine mimicry adaptation bet...
- Antibodies, Vol. 5, Pages 18: Antiphospholipid Ant...
- Humanities, Vol. 5, Pages 66: Of Pomo Academicus, ...
- Biosensors, Vol. 6, Pages 39: Electrochemical, Ele...
- Catalysts, Vol. 6, Pages 116: Recent Progress on M...
- Antioxidants, Vol. 5, Pages 26: Antioxidant Proper...
- Cancers, Vol. 8, Pages 73: Developmental Drift and...
- Societies, Vol. 6, Pages 23: Robots Working with H...
- Religions, Vol. 7, Pages 97: Between Socialism and...
- Toxins, Vol. 8, Pages 234: Putative Nonribosomal P...
- Sensors, Vol. 16, Pages 1216: Quantitative Determi...
- Toxins, Vol. 8, Pages 234: Putative Nonribosomal P...
- Sensors, Vol. 16, Pages 1210: Transducer Developme...
- IJMS, Vol. 17, Pages 1245: Impact of HIV Infection...
- Metals, Vol. 6, Pages 178: Understanding Low Cycle...
-
▼
Αυγ 02
(44)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.