Publication date: Available online 26 July 2016
Source:Vaccine
Author(s): Ann Lindstrand, Ilias Galanis, Jessica Darenberg, Eva Morfeldt, Pontus Naucler, Margareta Blennow, Tobias Alfvén, Birgitta Henriques-Normark, Åke Örtqvist
ObjectiveTo evaluate the carriage prevalence, serotype distribution, and antibiotic resistance for pneumococcal carriage isolates collected 4–8years after introduction of pneumococcal conjugate vaccines (PCVs) in Stockholm, Sweden, and to identify risk factors for carriage and calculate the invasive disease potential for emerging serotypes.MethodsNasopharyngeal aspirates were collected from 3024 children aged 0–<5years at regular visits at 23 Child Health Centers in Stockholm County in 2011–2015, and from 787 parents in 2014–2015. The invasive disease potential was calculated for serotypes using invasive disease isolates from 824 patients of all ages identified in the Stockholm County during the same time period as the carriage isolates.ResultsA total carriage prevalence of 30% did not change during the study period. Non-vaccine types (NVT) dominated (94% by 2015) and the most common serotypes in descending order were 11A, 23B, 35F and 21. Risk factors for carriage were: age ⩾3months–<3years, having siblings, attending day-care and having travelled abroad the last 3months. Antibiotic resistance remained low. The invasive disease potential was high for NVT 8, 9N, 12F, and 22F, while low for a majority of emerging NVTs in carriage.ConclusionThe carriage prevalence remained the same 4–8years after vaccine introduction, but serotype replacement became almost complete. A majority of emerging NVTs in carriage showed a low invasive disease potential. Carriage studies are an important complement to invasive disease surveillance to understand the full effect of PCV vaccine programs.
http://ift.tt/2a81KCp
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Ιουλίου
(489)
-
▼
Ιουλ 26
(50)
- Correction for Perry et al., Rapid behavioral matu...
- Left cortical tuning to print in preschoolers [Psy...
- Allosteric proteins as logarithmic sensors [System...
- ERK inhibition reverses defects in 16p dup neurons...
- Lmx1a/b regulate survival of dopamine neurons [Neu...
- Novel ncRNA, NfiS, optimizes nitrogen fixation [Mi...
- Mammalian ALOX15 evolution [Biochemistry]
- AKAP220 impacts renal water homeostasis [Cell Biol...
- R-loops, mutant RNase H1, and mtDNA disease [Bioch...
- Connectivity changes predict deficit after stroke ...
- Protein docking by manifold Fourier transforms [Bi...
- Mutational analysis of plant triterpene synthases ...
- Tension-based cell division in plants [Biophysics ...
- PI3K inhibitors induce nucleoside depletion [Medic...
- Speech-frequency hearing mechanisms [Biophysics an...
- Glycated albumin: correlation to HbA1c and prelimi...
- Commutable samples with assigned target concentrat...
- Comparison of Insulin Resistance and β-Cell Dysfun...
- A novel mutation in the CDH1 gene in a Spanish fam...
- Effect of skin infiltration with ropivacaine on po...
- Novel technique of vulvo-vaginal rejuvenation by l...
- Unaltered pneumococcal carriage prevalence due to ...
- Incompatibility of lyophilized inactivated polio v...
- Immunogenicity and safety of a fully liquid alumin...
- High-dose influenza vaccine favors acute plasmabla...
- Prediction of influenza B vaccine effectiveness fr...
- Concurrent hyperthyroidism and papillary thyroid c...
- Pyosalpinx causing acute appendicitis in a 32-year...
- Erratum to: 'Chinese medicine combined with calcip...
- Patient Preferences for Oral Anticoagulation Thera...
- Dietary ecology of fossil Theropithecus: Inference...
- Conditions de réalisation et description des princ...
- Virtual reconstruction of the Australopithecus afr...
- Combined proteomics and transcriptomics identifies...
- Proteomic analysis of soybean root exposed to vary...
- Integrative proteomic analysis reveals reprogramin...
- Hepatitis B virus X protein impairs α-interferon s...
- Myxovirus resistance 1 gene polymorphisms and outc...
- Molecular epidemiology of co-infection with hepati...
- Preliminary assessment of free radical scavenging,...
- Extraction and purification of total flavonoids fr...
- CO2-Responsive Polymer-Functionalized Au Nanoparti...
- Fluorogenic Enhancement of an in Vitro-Selected Pe...
- A System to Create Stable Nanoparticle Aerosols fr...
- Next-Generation Therapeutics for Inflammatory Bowe...
- Renin-angiotensin system in ventilator-induced dia...
- Is chondroitin sulfate responsible for the biologi...
- Recent Advances in Development and Application of ...
- Gas-Phase Microsolvation of Ubiquitin: Investigati...
- Epitaxial Growth of Perovskite Strontium Titanate ...
-
▼
Ιουλ 26
(50)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.