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Κυριακή 31 Ιουλίου 2016

Medicine Blogs

Swallowing and Swallowing Disorders (Dysphagia)
Validation of criteria for the definition of transient lower esophageal sphincter relaxations using high-resolution manometry
AbstractBackgroundCriteria for transient lower esophageal sphincter relaxations (TLESRs) are well-defined for Dentsleeve manometry. As high-resolution manometry (HRM) is now the gold standard to assess esophageal motility, our aim was to propose a consensus definition of TLESRs using HRM.MethodsPostprandial...
Swallowing and Swallowing Disorders (Dysphagia)
Effects of scFOS on the composition of fecal microbiota and anxiety in patients with irritable bowel syndrome: a randomized, double blind, placebo controlled study
AbstractBackgroundShort-chain fructooligosaccharides (scFOS) have beneficial effects in subjects with minor digestive complaints, but the potential mechanisms involved have not been elucidated. The aim of the study was to evaluate changes in rectal sensitivity related to the clinical effects of scFOS...
Swallowing and Swallowing Disorders (Dysphagia)
Sulfate-reducing bacteria slow intestinal transit in a bismuth-reversible fashion in mice
AbstractBackgroundHydrogen sulfide (H2S) serves as a mammalian cell-derived gaseous neurotransmitter. The intestines are exposed to a second source of this gas by sulfate-reducing bacteria (SRB). Bismuth subsalicylate binds H2S rendering it insoluble. The aim of this study was to test the hypothesis...
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Epidemiology of Invasive Group A Streptococcal Infections in the United States, 2005-2012
Background. Invasive group A Streptococcus (GAS) infections are associated with significant morbidity and mortality rates. We report the epidemiology and trends of invasive GAS over 8 years of surveillance. Methods. From January 2005 through December 2012, we collected data from the Centers for Disease...
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The Effect of Influenza Vaccination on Birth Outcomes in a Cohort of Pregnant Women in Lao PDR, 2014-2015
Background. Some studies suggest that maternal influenza vaccination can improve birth outcomes. However, there are limited data from tropical settings, particularly Southeast Asia. We conducted an observational study in Laos to assess the effect of influenza vaccination in pregnant women on birth outcomes....
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Neutralizing Anti-Interferon-Gamma Autoantibody Levels May Not Correlate With Clinical Course of Disease
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Reply to Lesho and Clifford
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Reply to Tham et al
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Blood-borne Hepatitis E Virus Transmission: A Relevant Risk for Immunosuppressed Patients
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Implementation of Molecular Surveillance After a Cluster of Fatal Toxoplasmosis at 2 Neighboring Transplant Centers
After a cluster of fatal toxoplasmosis among stem cell transplant recipients at 2 hospitals, surveillance with polymerase chain reaction (PCR) (blood) was instituted. Rate of reactivation among seropositive recipients was 2.2 and 16%. Parasitemia was successfully managed with preemptive treatment. For...
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Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America
It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate...
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For Rapid Molecular Detection, Why Not a Whole Genome Approach?
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Longitudinal Study of the Effects of Bacteremia and Sepsis on 5-year Risk of Cardiovascular Events
Background. The long-term and cumulative effect of multiple episodes of bacteremia and sepsis across multiple hospitalizations on the development of cardiovascular (CV) events is uncertain. Methods. We conducted a longitudinal study of 156 380 hospitalizations in 47 009 patients (≥18 years old) who...
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Initiation of Antiretroviral Therapy During Acute HIV-1 Infection Leads to a High Rate of Nonreactive HIV Serology
Background. Third- and fourth-generation immunoassays (IAs) are widely used in the diagnosis of human immunodeficiency virus (HIV) infection. Antiretroviral therapy (ART) during acute HIV infection (AHI) may impact HIV-specific antibodies, with failure to develop antibody or seroreversion. We report...
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Kinetic Analysis of Biomarkers in a Cohort of US Patients With Ebola Virus Disease
Background. Ebola virus (EBOV) infection causes a severe and often fatal disease. Despite the fact that more than 30 000 individuals have acquired Ebola virus disease (EVD), the medical and scientific community still does not have a clear understanding of the mechanisms by which EBOV causes such severe...
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Editorial Commentary: Toxoplasmosis: Cats Have It, Humans Get It, but How Much Disease Does It Cause?
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Factors Underlying Ebola Virus Infection Among Health Workers, Kenema, Sierra Leone, 2014-2015
Background. Ebola virus disease (EVD) in health workers (HWs) has been a major challenge during the 2014–2015 outbreak. We examined factors associated with Ebola virus exposure and mortality in HWs in Kenema District, Sierra Leone. Methods. We analyzed data from the Sierra Leone National Viral Hemorrhagic...
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Understanding Toxoplasmosis in the United States Through "Large Data" Analyses
Background. Toxoplasma gondii infection causes substantial morbidity and mortality in the United States, and infects approximately one-third of persons globally. Clinical manifestations vary. Seropositivity is associated with neurologic diseases and malignancies. There are few objective data concerning...
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Antiretroviral Therapy to Prevent HIV Acquisition in Serodiscordant Couples in a Hyperendemic Community in Rural South Africa
Background. Antiretroviral therapy (ART) was highly efficacious in preventing human immunodeficiency virus (HIV) transmission in stable serodiscordant couples in the HPTN-052 study, a resource-intensive randomized controlled trial with near-perfect ART adherence and mutual HIV status disclosure among...
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Marijuana Use Is Not Associated With Progression to Advanced Liver Fibrosis in HIV/Hepatitis C Virus-coinfected Women
Background. Marijuana (hereafter "tetrahydrocannabinol [THC]") use has been associated with liver fibrosis progression in retrospective analyses of patients with chronic hepatitis C (HCV). We studied long-term effects of THC on fibrosis progression in women coinfected with human immunodeficiency virus...
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Approaches to Modifying the Behavior of Clinicians Who Are Noncompliant With Antimicrobial Stewardship Program Guidelines
Antimicrobial stewardship programs (ASPs) are a key national initiative to promote appropriate use of antibiotics and to reduce the burden of resistance. The dilemma of managing the outlier physician is especially complex. We outline strategies to establish a successful ASP that reviews appropriate efforts...
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Impact and Effectiveness of the Quadrivalent Human Papillomavirus Vaccine: A Systematic Review of 10 Years of Real-world Experience
Prophylactic human papillomavirus (HPV) vaccination programs constitute major public health initiatives worldwide. We assessed the global effect of quadrivalent HPV (4vHPV) vaccination on HPV infection and disease. PubMed and Embase were systematically searched for peer-reviewed articles from January...
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Editorial Commentary: Timing Is Everything: Shortcomings of Current HIV Diagnostics in the Early Treatment Era
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Ydjn encodes an S-sulfocysteine transporter required by Escherichia coli for growth on S-sulfocysteine as a sulfur source
Sulfur is an essential element for growth and many physiological functions. As sulfur sources for Escherichia coli and related bacteria, specific transporters import various sulfur-containing compounds from the environment. In this study, we identified and characterized an alternative function of the...
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Inhibition by fructose 1,6-bisphosphate of transaldolase from Escherichia coli
The effect of fructose 1,6-bisphosphate (Fru 1,6-P2) on the regulatory enzymes of pentose phosphate pathway of Escherichia coli was examined. Fru 1,6-P2 inhibited E. coli transaldolase (EC 2.2.1.2) competitively against fructose 6-phosphate and uncompetitively against erythrose 4-phosphate, whereas Fru...
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A novel prophage lysin Ply5218 with extended lytic activity and stability against Streptococcus suis infection
Streptococcus suis (S. suis) is an emerging zoonotic agent that exhibits high level resistance to classic antibiotics and heavy burden in the swine industry. Thus, alternative antibacterial agents need to be developed. A novel endolysin derived from the S. suis temperate phage phi5218, termed Ply5218,...
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Membrane localization and topology of the DnpA protein control fluoroquinolone tolerance in Pseudomonas aeruginosa
DnpA, a putative de-N-acetylase of the PIG-L superfamily, is required for antibiotic tolerance in Pseudomonas aeruginosa. Exactly how dnpA (gene locus PA5002) directs the formation of antibiotic-tolerant persister cells is currently unknown. Previous research provided evidence for a role in surface-associated...
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Simultaneous detection of somatic and F-Specific coliphages in different settings by Escherichia coli strain CB390
Bacteriophages are increasingly being used as water quality indicators. Two groups of phages infecting Escherichia coli, somatic and F-specific coliphages, are being considered as indicators of fecal and viral contamination for several types of water around the world. However, some uncertainties remain...
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Effects of MreB paralogs on poly-{gamma}-glutamic acid synthesis and cell morphology in Bacillus amyloliquefaciens
Actin-like MreB paralogs play important roles in cell shape maintenance, cell wall synthesis and the regulation of the D,L-endopeptidases, CwlO and LytE. The gram-positive bacteria, Bacillus amyloliquefaciens LL3, is a poly--glutamic acid (-PGA) producing strain that contains three MreB paralogs: MreB,...
ΩΡΛ Ιατρικά Άρθρα απ' το Μελετητή
Ειδοποίηση Μελετητή - [ Thyroid ]
Ειδοποίηση Μελετητή:[ Thyroid ]Efficacy and safety of ultrasound guided radiofrequency ablation for treating low risk papillary thyroid microcarcinoma: a prospective studyM Zhang, Y Luo, Y Zhang, J Tang - Thyroid, 2016Background. Papillary thyroid microcarcinoma (PTMC) has a high incidence and a good...
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Ειδοποίηση Μελετητή - [ Larynx's Diseases ]
Ειδοποίηση Μελετητή:[ Larynx's Diseases ][HTML] Is a preoperative gastrointestinal endoscopy for second primary cancer detection in head and neck cancer necessary? Ten-year registry dataGM Heo, MH Kim, JH Kim, YS Rho, WG Shin - The Korean Journal of …, 2016... who had a cancer located in the oral cavity,...
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Ειδοποίηση Μελετητή - [ Ear's Diseases ]
Ειδοποίηση Μελετητή:[ Ear's Diseases ]Evaluation of Ventilation Tube Placement and Long-term Audiologic Outcome in Children With Cleft PalateE Kim, MD Kanack, MD Dang-Vu, D Carvalho… - The Cleft Palate- …, 2016... Conclusions: While children with worse middle ear disease are more likely to receive more...
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Ειδοποίηση Μελετητή - [ Vertigo ]
Ειδοποίηση Μελετητή:[ Vertigo ][PDF] Differential Diagnosis of Headache and Vertigo: Topical Minoxidil Self-medication Should Be ConsideredAM Das - Journal of Headache & Pain, 2016Abstract We describe a girl with headache and dizziness presumably caused by topical minoxidil (2%) treatment. Minoxidil...

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