Publication date: 8 June 2016
Source:Vaccine, Volume 34, Issue 27
Author(s): Christopher Schutta, José Barrera, Melia Pisano, Laszlo Zsak, Marvin J. Grubman, Gregory A. Mayr, Mauro P. Moraes, Barbara J. Kamicker, David A. Brake, Damodar Ettyreddy, Douglas E. Brough, Bryan T. Butman, John G. Neilan
The safety and efficacy of an experimental, replication-deficient, human adenovirus-vectored foot-and-mouth disease virus (FMDV) serotype A24 Cruzeiro capsid-based subunit vaccine (AdtA24) was examined in eight independent cattle studies. AdtA24 non-adjuvanted vaccine was administered intramuscularly to a total of 150 steers in doses ranging from approximately 1.0×108 to 2.1×1011 particle units per animal. No detectable local or systemic reactions were observed after vaccination. At 7 days post-vaccination (dpv), vaccinated and control animals were challenged with FMDV serotype A24 Cruzeiro via the intradermal lingual route. Vaccine efficacy was measured by FMDV A24 serum neutralizing titers and by protection from clinical disease and viremia after challenge. The results of eight studies demonstrated a strong correlation between AdtA24 vaccine dose and protection from clinical disease (R2=0.97) and viremia (R2=0.98). There was also a strong correlation between FMDV A24 neutralization titers on day of challenge and protection from clinical disease (R2=0.99). Vaccination with AdtA24 enabled differentiation of infected from vaccinated animals (DIVA) as demonstrated by the absence of antibodies to the FMDV nonstructural proteins in vaccinates prior to challenge. Lack of AdtA24 vaccine shedding after vaccination was indicated by the absence of neutralizing antibody titers to both the adenovector and FMDV A24 Cruzeiro in control animals after co-mingling with vaccinated cattle for three to four weeks. In summary, a non-adjuvanted AdtA24 experimental vaccine was shown to be safe, immunogenic, consistently protected cattle at 7 dpv against direct, homologous FMDV challenge, and enabled differentiation of infected from vaccinated cattle prior to challenge.
from #Medicine via ola Kala on Inoreader http://ift.tt/1U1hwzC
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Ιουνίου
(946)
-
▼
Ιουν 04
(22)
- Revisiting the resilience of Late Archaic hunter-g...
- Holocene cold storage practices on the eastern Sna...
- Apricot Kernel Oil Ameliorates Cyclophosphamide-As...
- A Rapid Strategy for the Isolation of New Faustovi...
- RNA Purification from Intracellularly Grown Lister...
- Venous anomaly analogous to vertical embryonic pos...
- Syndrome of transient headache with neurologic def...
- Delayed diagnosis of cervical spinal cord transect...
- Real-World Effectiveness and Safety of a Live-Atte...
- Multiple efficacy studies of an adenovirus-vectore...
- Control of Ixodes ricinus and Dermacentor reticula...
- Editorial Board/Aims and Scope
- A population profile of measles susceptibility in ...
- Emergence of antigenic variants within serotype A ...
- Effect of high and low levels of maternally derive...
- Impact of enterovirus and other enteric pathogens ...
- Vaccination against H5 avian influenza virus induc...
- Immune effects of the vaccine of live attenuated A...
- Heparan sulfates targeting increases MHC class I- ...
- CRACC-targeting Fc-fusion protein induces activati...
- Low level lead exposure and pregnancy outcomes in ...
- The source of SYBR green master mix determines out...
-
▼
Ιουν 04
(22)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.