The proportion of foodborne disease caused by pathogenic microorganisms is rising worldwide, with staphylococcal food poisoning being one of the main causes of this increase. Juglone is a plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities. However, the specific mechanism underlying its antibacterial activity against Staphylococcus aureus remains unclear. To elucidate the mechanism underlying its antibacterial activity, isobaric tags for relative and absolute quantitation methods of quantitative proteomics were applied for analysis of the 53 proteins that were differentially expressed after treatment with juglone. Combined with verification experiments, such as detection of changes in DNA and RNA content and quantification of oxidative damage, our results suggested that juglone effectively increased the protein expression of oxidoreductase and created a peroxidative environment within the cell, significantly reducing cell wall formation and increasing membrane permeability. We hypothesize that juglone binds to DNA and reduces DNA transcription and replication directly. This is the first study to adopt a proteomic approach to investigate the antibacterial mechanism of juglone.
from #Medicine via ola Kala on Inoreader http://ift.tt/1W4WkeB
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Ιουνίου
(946)
-
▼
Ιουν 17
(40)
- Predicting Intracranial Pressure and Brain Tissue ...
- Liberal Glycemic Control in Critically Ill Patient...
- Remote Sensing, Vol. 8, Pages 515: Large-Area, Hig...
- IJMS, Vol. 17, Pages 965: Antibacterial Activity o...
- Polymers, Vol. 8, Pages 238: Exploring the Behavio...
- Sida coordinators get inspired about innovation an...
- IJERPH, Vol. 13, Pages 609: Crash Frequency Modeli...
- Sustainability, Vol. 8, Pages 565: Soil Conservati...
- Fluids, Vol. 1, Pages 19: On Thermomechanics of a ...
- Toxics, Vol. 4, Pages 11: UNMIX Methods Applied to...
- Sustainability, Vol. 8, Pages 571: Residents’ Envi...
- Remote Sensing, Vol. 8, Pages 513: Object-Based Gr...
- Sustainability, Vol. 8, Pages 572: Beef Cattle Far...
- Foods, Vol. 5, Pages 44: Evaluation of the Bittern...
- Eukaryote-specific rRNA expansion segments functio...
- IJMS, Vol. 17, Pages 964: Benzbromarone, Quercetin...
- MCDA Twins with Discordant Malformations: Submicro...
- IJERPH, Vol. 13, Pages 605: Generalized Confidence...
- Remote Sensing, Vol. 8, Pages 511: Using the NASA ...
- IJERPH, Vol. 13, Pages 607: Risky Substance Use En...
- Effect of dust size distribution and dust charge f...
- Quantum mechanics of P T $\mathcal {P}\mathcal {T}...
- An update on cardiovascular effects of obstructive...
- Carotid artery stenting versus carotid endarterectomy
- Surface-Enhanced Raman Spectroscopy Biosensing: In...
- Single-Cell-Arrayed Agarose Chip for in Situ Analy...
- Visualization of Diffusion within Nanoarrays
- Excess deaths due to occupation
- Soma to germline inheritance of extrachromosomal g...
- Evolution of sex: Using experimental genomics to s...
- Has inheritance gone retro?
- Effects of continuous and intermittent exercise on...
- Delayed extinction fails to reduce skin conductanc...
- Vessel Segmentation From Abdominal MR Images: Adap...
- Satisfaction, Adherence and Health-Related Quality...
- Toxins, Vol. 8, Pages 189: The Sialidase NanS Enha...
- Evaluation of a tissue-mimicking thermochromic pha...
- Hypoxia Analysis in Head and/or Neck Cancer
- Inovio TRT-001: Telomerase DNA Immunotherapy in Br...
- IJMS, Vol. 17, Pages 956: Human Milk Cells Contain...
-
▼
Ιουν 17
(40)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Παρασκευή 17 Ιουνίου 2016
IJMS, Vol. 17, Pages 965: Antibacterial Activity of Juglone against Staphylococcus aureus: From Apparent to Proteomic
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.