Radiolabeled antibodies (mAbs) provide efficient tools for cancer therapy. The combination of low energy β−-emissions (500 keVmax; 130 keVave) along with a γ-emission for imaging makes 177Lu (T1/2 = 6.7 day) a suitable radionuclide for radioimmunotherapy (RIT) of tumor burdens possibly too large to treat with α-particle radiation. RIT with 177Lu-trastuzumab has proven to be effective for treatment of disseminated HER2 positive peritoneal disease in a pre-clinical model. To elucidate mechanisms originating from this RIT therapy at the molecular level, tumor bearing mice (LS-174T intraperitoneal xenografts) were treated with 177Lu-trastuzumab comparatively to animals treated with a non-specific control, 177Lu-HuIgG, and then to prior published results obtained using 212Pb-trastuzumab, an α-particle RIT agent. 177Lu-trastuzumab induced cell death via DNA double strand breaks (DSB), caspase-3 apoptosis, and interfered with DNA-PK expression, which is associated with the repair of DNA non-homologous end joining damage. This contrasts to prior results, wherein 212Pb-trastuzumab was found to down-regulate RAD51, which is involved with homologous recombination DNA damage repair. 177Lu-trastuzumab therapy was associated with significant chromosomal disruption and up-regulation of genes in the apoptotic process. These results suggest an inhibition of the repair mechanism specific to the type of radiation damage being inflicted by either high or low linear energy transfer radiation. Understanding the mechanisms of action of β−- and α-particle RIT comparatively through an in vivo tumor environment offers real information suitable to enhance combination therapy regimens involving α- and β−-particle RIT for the management of intraperitoneal disease.
from #Medicine via ola Kala on Inoreader http://ift.tt/1VYgYxv
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Μαΐου
(630)
-
▼
Μαΐ 16
(53)
- IJMS, Vol. 17, Pages 731: Key Developments in Ioni...
- Laws, Vol. 5, Pages 23: Are Cutbacks to Personal A...
- IJMS, Vol. 17, Pages 736: Mechanisms of Cell Killi...
- IJMS, Vol. 17, Pages 742: Recent Progress in Treat...
- Nutrients, Vol. 8, Pages 297: Persistent Inequalit...
- Applied Sciences, Vol. 6, Pages 150: State of the ...
- Sustainability, Vol. 8, Pages 482: ELV Recycling S...
- Sensors, Vol. 16, Pages 705: Xurography as a Rapid...
- Sensors, Vol. 16, Pages 704: Kinect-Based Virtual ...
- Entropy, Vol. 18, Pages 184: Selection of Entropy ...
- Remote Sensing, Vol. 8, Pages 417: Retrieval of Ae...
- Societies, Vol. 6, Pages 18: The Portrayal of Occu...
- Nutrients, Vol. 8, Pages 298: Adequate Iodine Stat...
- miR-155 as a Biomarker in B-Cell Malignancies
- IJGI, Vol. 5, Pages 69: Assessment on the Impact o...
- Water, Vol. 8, Pages 204: Stakeholder Engagement f...
- Systems, Vol. 4, Pages 21: A Knowledge Comparison ...
- JLPEA, Vol. 6, Pages 7: A 36 nW, 7 ppm/°C on-Chip ...
- Entropy, Vol. 18, Pages 186: Quantum Thermodynamic...
- Energies, Vol. 9, Pages 374: Chemical Analysis of ...
- Energies, Vol. 9, Pages 372: Black Start Strategy ...
- Energies, Vol. 9, Pages 368: Assessment of the Var...
- IJERPH, Vol. 13, Pages 502: Prevalence and Factors...
- Applied Sciences, Vol. 6, Pages 152: Superhydropho...
- Sensors, Vol. 16, Pages 703: Anchoring of FRET Sen...
- Hepatitis C virus genotype 4 replication in the he...
- FOLFIRINOX for locally advanced pancreatic cancer:...
- The Hippo pathway in intestinal regeneration and d...
- Parallel declines in HIV and hepatitis C virus pre...
- Factors predicting adverse events associated with ...
- Effect of fibre supplementation on chronic idiopat...
- Immunologic and metabolic features of pancreatic d...
- Effectiveness of add-on therapy with domperidone v...
- Allele-specific transcriptional activity of the va...
- Hepatitis E virus mutations associated with ribavi...
- Full title: a meta-analysis of the diagnostic valu...
- Multiple hepatitis B virus (HBV) quasispecies and ...
- Biologic therapies and risk of infection and malig...
- The all-age prevalence of Helicobacter pylori infe...
- Applied Sciences, Vol. 6, Pages 153: Reduction of ...
- IJGI, Vol. 5, Pages 67: Using Moderate-Resolution ...
- Toxins, Vol. 8, Pages 145: Degradation of Swainson...
- Water, Vol. 8, Pages 203: Combination of Assessmen...
- Entropy, Vol. 18, Pages 185: An Information Entrop...
- Remote Sensing, Vol. 8, Pages 416: Remote Estimati...
- Extracorporeal Membrane Oxygenation as a Bridge fo...
- Remote Sensing, Vol. 8, Pages 415: Three-Dimension...
- Diagnostics, Vol. 6, Pages 20: Real-Time Monitorin...
- Remote Sensing, Vol. 8, Pages 420: Diatom Phenolog...
- Viruses, Vol. 8, Pages 136: The Effect of MicroRNA...
- Energies, Vol. 9, Pages 369: Effects of Different ...
- Molbank, Vol. 2016, Article M899: 6-Nitro-4H-benzo...
- Energies, Vol. 9, Pages 371: Experimental Attempts...
-
▼
Μαΐ 16
(53)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.