Objectives: To determine the time-dependent effect of antibiotics on the initial acquisition of carbapenem-resistant Acinetobacter baumannii. Design: Retrospective cohort study. Setting: Forty-bed trauma ICU in Miami, FL. Patients: All consecutive patients admitted to the unit from January 2010 to November 2011. Interventions: None. Measurements and Main Results: Patients underwent surveillance cultures at admission to the unit and weekly thereafter. The primary outcome was the acquisition of carbapenem-resistant A. baumannii on surveillance cultures. Daily antibiotic exposures during the time of observation were used to construct time-dependent variables, including cumulative exposures (in grams and daily observed doses [defined daily doses]). Among 360 patients, 45 (12.5%) became colonized with carbapenem-resistant A. baumannii. Adjusted Cox models showed that each additional point in the Acute Physiologic and Chronic Health Evaluation score increased the hazard by 4.8% (hazard ratio, 1.048; 95% CI, 1.010-1.087; p = 0.0124) and time-dependent exposure to carbapenems quadrupled the hazard (hazard ratio, 4.087; 95% CI, 1.873-8.920; p = 0.0004) of acquiring carbapenem-resistant A. baumannii. Additionally, adjusted Cox models determined that every additional carbapenem defined daily dose increased the hazard of acquiring carbapenem-resistant A. baumannii by 5.1% (hazard ratio, 1.051; 95% CI, 1.007-1.093; p = 0.0243). Conclusions: Carbapenem exposure quadrupled the hazards of acquiring A. baumannii even after controlling for severity of illness. Copyright (C) by 2016 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
from #Medicine via ola Kala on Inoreader http://ift.tt/1X3bUqw
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Μαΐου
(630)
-
▼
Μαΐ 12
(50)
- A preliminary study of how the viscosity of dietar...
- IJERPH, Vol. 13, Pages 494: Prevention of Asbestos...
- Toxins, Vol. 8, Pages 144: Two Novel Dermaseptin-L...
- Sensors, Vol. 16, Pages 688: Particle and Photon D...
- Future Internet, Vol. 8, Pages 19: Computational S...
- Sensors, Vol. 16, Pages 670: Model-Driven Approach...
- IJERPH, Vol. 13, Pages 493: Factors Affecting Pare...
- Sustainability, Vol. 8, Pages 471: Wetland Transit...
- Nanomaterials, Vol. 6, Pages 89: Modification of t...
- Metals, Vol. 6, Pages 110: Melt Processing and Cha...
- Energies, Vol. 9, Pages 359: Techno-Economic Analy...
- Sensors, Vol. 16, Pages 678: An in-Depth Survey of...
- IJERPH, Vol. 13, Pages 484: Effects of Fine Partic...
- Applied Sciences, Vol. 6, Pages 147: Physical and ...
- Information, Vol. 7, Pages 24: Super-Activation as...
- Games, Vol. 7, Pages 12: Time-Preference Heterogen...
- Evaluating the Impact of Antibiotic Exposures as T...
- Quantitative interactome reveals that porcine repr...
- Xanthomonas citri subsp. citri surface proteome by...
- Comprehensive Quantification of N-Glycoproteome in...
- Forests, Vol. 7, Pages 103: Regional Instability i...
- Cells, Vol. 5, Pages 23: The Ubiquitination of NF-...
- Sustainability, Vol. 8, Pages 469: Effect of the I...
- Bioengineering, Vol. 3, Pages 14: Biodiesel Produc...
- Association between SNP12 in estrogen receptor α g...
- Effect of risk factors on the prevalence of influe...
- Whole-cell conversion of l-glutamic acid into gamm...
- Reconstruction of acetabulum in revision total hip...
- Impact of central obesity on prognostic outcome of...
- Screening of Bioactivities and Toxicity of Cnidosc...
- GC-MS Analysis: In Vivo Hepatoprotective and Antio...
- Genotyping-by-sequencing in an orphan plant specie...
- Subclinical inflammation in relation to insulin re...
- Using qualitative research methods in biomedical i...
- A Comparison between Three-Dimensional Visualizati...
- Sensors, Vol. 16, Pages 681: Self-Mixing Demodulat...
- Sustainability, Vol. 8, Pages 472: Potential for E...
- Sensors, Vol. 16, Pages 684: Communication Range D...
- Sustainability, Vol. 8, Pages 470: Developing an I...
- Marine Drugs, Vol. 14, Pages 94: Bacterial Long-Ch...
- Patterns of Growth and Decline in Lung Function in...
- Clinical Significance of Symptoms in Smokers with ...
- One-Year Outcomes in Caregivers of Critically Ill ...
- Life, Vol. 6, Pages 19: Hans Georg Trüper (1936–20...
- Forests, Vol. 7, Pages 104: Joining Criteria for H...
- Sustainability, Vol. 8, Pages 473: Erratum: Wu, C....
- Energies, Vol. 9, Pages 362: Dynamic Equivalent Mo...
- Crystals, Vol. 6, Pages 54: Bottom-Up Assembly and...
- J. Imaging, Vol. 2, Pages 18: Microwave Imaging Ra...
- Water, Vol. 8, Pages 195: Regional Quasi-Three-Dim...
-
▼
Μαΐ 12
(50)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.