Objective: Noble gases have been attributed to organ protective effects in ischemia reperfusion injury in a variety of medical conditions, including cerebral and cardiac ischemia, acute kidney injury, and transplantation. The aim of this study was to appraise the available evidence by systematically reviewing the literature and performing meta-analyses. Data Sources: PubMed, EMBASE, and the Cochrane Library. Study Selection: Inclusion criteria specified any articles on noble gases and either ischemia reperfusion injury or transplantation. In vitro studies, publications without full text, review articles, and letters were excluded. Data Extraction: Information on noble gas, organ, species, model, length of ischemia, conditioning and noble gas dose, duration of administration of the gas, endpoints, and effects was extracted from 79 eligible articles. Study quality was evaluated using the Jadad scale. Effect sizes were extracted from the articles or retrieved from the authors to allow meta-analyses using the random-effects approach. Data Synthesis: Argon has been investigated in cerebral, myocardial, and renal ischemia reperfusion injury; helium and xenon have additionally been tested in hepatic ischemia reperfusion injury, whereas neon was only explored in myocardial ischemia reperfusion injury. The majority of studies show a protective effect of these noble gases on ischemia reperfusion injury across a broad range of experimental conditions, organs, and species. Overall study quality was low. Meta-analysis for argon was only possible in cerebral ischemia reperfusion injury and did not show neuroprotective effects. Helium proved neuroprotective in rodents and cardioprotective in rabbits, and there were too few data on renal ischemia reperfusion injury. Xenon had the most consistent effects, being neuroprotective in rodents, cardioprotective in rodents and pigs, and renoprotective in rodents. Conclusions: Helium and xenon show organ protective effects mostly in small animal ischemia reperfusion injury models. Additional information on timing, dosing, and comparative efficacy of the different noble gases, as well as confirmation in large animal models, is needed before designing clinical trials. Copyright (C) by 2016 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
from #Medicine via ola Kala on Inoreader http://ift.tt/1VTQrzL
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Απριλίου
(500)
-
▼
Απρ 13
(50)
- Metformin use and survival of patients with pancre...
- Ischemic colitis as a complication of medication u...
- Cost-effectiveness of Crohn’s disease post-operati...
- Sphingosine-1-phosphate receptor-1 (S1P1) is expre...
- Acceptability of rapid point-of-care hepatitis C t...
- Metformin enhances the response to radiotherapy in...
- The prognostic value of lactate dehydrogenase leve...
- The prognostic value of rectal invasion for stage ...
- Gastrointestinal tract colonization dynamics by di...
- Entropy, Vol. 18, Pages 133: Correction on Liu, X....
- Entropy, Vol. 18, Pages 136: Correction: Kay, B.S....
- Incidence and Etiology of Potentially Preventable ...
- Critical Illness Is Associated With Impaired Gallb...
- Cerebral Oximetry During Cardiac Arrest: A Multice...
- Pediatric Triage in a Severe Pandemic: Maximizing ...
- Cardiac Arrests Associated With Tracheal Intubatio...
- Elevated Leukocyte Azurophilic Enzymes in Human Di...
- The Efficacy of Noble Gases in the Attenuation of ...
- Acute and Subchronic Oral Toxicity Evaluation of A...
- Sustainability, Vol. 8, Pages 362: Solar Energy Bl...
- Geosciences, Vol. 6, Pages 22: An Overview of the ...
- Sustainability, Vol. 8, Pages 361: An Optimization...
- Crystals, Vol. 6, Pages 42: Rb2Na(NO3)3: A Congrue...
- Sustainability, Vol. 8, Pages 364: Conceptualizing...
- Metals, Vol. 6, Pages 85: Corrosion Resistance of ...
- Buildings, Vol. 6, Pages 17: Design of Sustainable...
- IJERPH, Vol. 13, Pages 420: Restoration in Its Nat...
- Life, Vol. 6, Pages 18: Molecular Asymmetry in Pre...
- Water, Vol. 8, Pages 143: Can Rapid Assessments Pr...
- Sensors, Vol. 16, Pages 531: Towards A Self Adapti...
- Toxins, Vol. 8, Pages 107: Review Over a 3-Year Pe...
- JCM, Vol. 5, Pages 47: Management of Status Epilep...
- Polymers, Vol. 8, Pages 139: Enzyme-Catalyzed Synt...
- Micromachines, Vol. 7, Pages 66: Micro-Shaping of ...
- Sensors, Vol. 16, Pages 528: Development of a Low-...
- Toxins, Vol. 8, Pages 109: Metal Ion Activation of...
- IJERPH, Vol. 13, Pages 415: Pain Assessment–Can it...
- Nanomaterials, Vol. 6, Pages 68: Gold Nanomaterial...
- Applied Sciences, Vol. 6, Pages 108: WIPP: Wi-Fi C...
- Atmosphere, Vol. 7, Pages 56: Assessment of Air Qu...
- Sensors, Vol. 16, Pages 530: MGRA: Motion Gesture ...
- Toxins, Vol. 8, Pages 109: Metal Ion Activation of...
- Plants, Vol. 5, Pages 17: Canola/Rapeseed Protein:...
- Vision, Vol. 1, Pages 2: Comparing Macular Thickne...
- Improving distress in dialysis (iDiD): a feasibili...
- Opportunistic screening of atrial fibrillation by ...
- Combined early and adult life risk factor associat...
- Molecular genetics and epigenetics of nonfamilial ...
- Development and significance of automated history-...
- The effect of tailored Web-based interventions on ...
-
▼
Απρ 13
(50)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.