Background. This randomized, multicenter, open-label clinical trial was intended to generate pilot data on the efficacy and safety of the gonadotropin-releasing hormone agonist (GnRHa) deslorelin (D) with low-dose estradiol ± testosterone (E2 ± T) add-back for endometriosis-related pelvic pain. Methods. Women with pelvic pain and laparoscopically confirmed endometriosis were treated with a six-month course of daily intranasal D with concurrent administration of either transdermal E2, intranasal E2, or intranasal E2 + T. Efficacy data included evaluation of dyspareunia, dysmenorrhea, pelvic pain, tenderness, and induration. Cognition and quality of life were also assessed. Safety parameters included assessment of endometrial hyperplasia, bone mineral density (BMD), and hot flashes. Results. Endometriosis symptoms and signs scores decreased in all treatment arms from a baseline average of 7.4 to 2.5 after 3 months of treatment and 3.4 after 6 months. BMD changes and incidence of hot flashes were minimal, and no endometrial hyperplasia was observed. Patient-reported outcomes showed significant improvement across multiple domains. Conclusions. Daily intranasal D with low dose E2 ± T add-back resulted in significant reduction in severity of endometriosis symptoms and signs with few safety signals and minimal hypoestrogenic symptoms that would be expected with the use of a GnRHa alone.
from #Medicine via ola Kala on Inoreader http://ift.tt/1On3J4U
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
-
▼
Δεκεμβρίου
(940)
-
▼
Δεκ 31
(58)
- Impacts of motivational valence on the error-relat...
- Rotating Ring-Disk Electrode Method for the Detect...
- Adsorbent Assisted in Situ Electrocatalysis: An Ul...
- Step-specific Sorting of Mouse Spermatids by Flow ...
- Fuzheng Huayu Recipe Ameliorates Liver Fibrosis by...
- Treatment of Endometriosis with the GnRHa Deslorel...
- Contrast-Enhanced Ultrasonography Features of Brea...
- Therapeutic analysis of high-dose-rate 192Ir vagin...
- Fast leaf-fitting with generalized underdose/overd...
- Hospitals Patterns of Use of Noninvasive Ventilati...
- Cardiac dysfunction after neurologic injury: What ...
- Comorbidome, pattern and impact of asthma-COPD ove...
- Reduced anti-viral interferon production in poorly...
- Lung Ultrasound for Early Diagnosis of Ventilator-...
- Additional Effects of Back-Shu Electroacupuncture ...
- Temporal regularization of ultrasound-based liver ...
- Limited-angle effect compensation for respiratory ...
- IJMS, Vol. 17, Pages 55: Global Gene Expression Al...
- IJMS, Vol. 17, Pages 51: Molecular Evolution of Ar...
- IJMS, Vol. 17, Pages 52: Role for the Unfolded Pro...
- JoF, Vol. 2, Pages 4: Severe Dermatophytosis and A...
- JRFM, Vol. 9, Pages 1: The Two Defaults Scenario f...
- Pathogens, Vol. 5, Pages 1: Development of a Vacci...
- Life, Vol. 6, Pages 2: Perspectives and Insights i...
- Nanomaterials, Vol. 6, Pages 5: Biosensors Incorpo...
- Nutrients, Vol. 8, Pages 20: Associations between ...
- Polymers, Vol. 8, Pages 7: Recent Progress and Per...
- Sports, Vol. 4, Pages 1: Effects of Video-Based Vi...
- Enhanced and Secretory Expression of Human Granulo...
- Benign phyllodes tumor of the vulva: a case report...
- Undifferentiated embryonal sarcoma of liver
- Technologies, Vol. 4, Pages 2: Fate and Transport ...
- Crystals, Vol. 6, Pages 6: Constructor Graphs as U...
- Cells, Vol. 5, Pages 1: MIRO GTPases in Mitochondr...
- Axioms, Vol. 5, Pages 1: On some Integral Represen...
- JCM, Vol. 5, Pages 3: The Effect of Marine Derived...
- Algorithms, Vol. 9, Pages 5: A Family of Iterative...
- Coatings, Vol. 6, Pages 1: State of the Art in the...
- Cancers, Vol. 8, Pages 5: Cancer Stem Cells and Th...
- Genes, Vol. 7, Pages 1: Analysis of DNA Methylatio...
- Membranes, Vol. 6, Pages 7: Treatment of the Bleac...
- Molecules, Vol. 21, Pages 55: Silymarin Constituen...
- Atmosphere, Vol. 7, Pages 5: Variation Characteris...
- Membranes, Vol. 6, Pages 6: Analytical and Finite ...
- Molecules, Vol. 21, Pages 30: Synthesis and Cytoto...
- IJERPH, Vol. 13, Pages 95: Racial Differences in L...
- Atmosphere, Vol. 7, Pages 4: Multi-Scale Observati...
- Atmosphere, Vol. 7, Pages 6: Comprehensive Evaluat...
- Molecules, Vol. 21, Pages 54: DNA Binding, Photonu...
- Entropy, Vol. 18, Pages 17: Three-Dimensional Latt...
- Resistance analysis and characterization of NITD00...
- Inducing tolerability of adverse events increases ...
- Dietary pattern, serum magnesium, ferritin, C-reac...
- Ferric carboxymaltose reduces transfusions and hos...
- Aspartate β-hydroxylase modulates cellular senesce...
- Serum hepatitis B core-related antigen as a treatm...
- Probiotics and prebiotics in infectious gastroente...
- Management of postoperative bladder emptying after...
-
▼
Δεκ 31
(58)
-
▼
Δεκεμβρίου
(940)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 31 Δεκεμβρίου 2015
Treatment of Endometriosis with the GnRHa Deslorelin and Add-Back Estradiol and Supplementary Testosterone
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.