Roles for mismatch repair family proteins in promoting meiotic crossing over

Publication date: Available online 2 December 2015
Source:DNA Repair
Author(s): Carol M. Manhart, Eric Alani
The mismatch repair (MMR) family complexes Msh4-Msh5 and Mlh1-Mlh3 act with Exo1 and Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the asymmetric cleavage of double Holliday junctions (dHJ) to form crossovers. This review discusses how meiotic roles for Msh4-Msh5 and Mlh1-Mlh3 do not fit paradigms established for post-replicative MMR. We also outline models used to explain how these factors promote the formation of meiotic crossovers required for the accurate segregation of chromosome homologs during the Meiosis I division.



from #Medicine via ola Kala on Inoreader http://ift.tt/21wTK2C
via IFTTT