Articular cartilage (AC) covers the diarthrodial joints and is responsible for the mechanical distribution of loads across the joints. The majority of its structure and function is controlled by chondrocytes that regulate Extracellular Matrix (ECM) turnover and maintain tissue homeostasis. Imbalance in their function leads to degenerative diseases like Osteoarthritis (OA). OA is characterized by cartilage degradation, osteophyte formation and stiffening of joints. Cartilage degeneration is a consequence of chondrocyte hypertrophy along with the expression of proteolytic enzymes. Matrix Metalloproteinases (MMPs) and A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) are an example of these enzymes that degrade the ECM. Signaling cascades involved in limb patterning and cartilage repair play a role in OA progression. However, the regulation of these remains to be elucidated. Further the role of stem cells and mature chondrocytes in OA progression is unclear. The progress in cell based therapies that utilize Mesenchymal Stem Cell (MSC) infusion for cartilage repair may lead to new therapeutics in the long term. However, many questions are unanswered such as the efficacy of MSCs usage in therapy. This review focuses on the role of chondrocytes in cartilage formation and the progression of OA. Moreover, it summarizes possible alternative therapeutic approaches using MSC infusion for cartilage restoration.
from #Medicine via ola Kala on Inoreader http://ift.tt/22cHOTX
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
-
▼
Δεκεμβρίου
(940)
-
▼
Δεκ 18
(50)
- Cortical trajectories during adolescence in preter...
- Viruses, Vol. 7, Pages 6739-6754: Ebola Virus Infe...
- Sensors, Vol. 15, Pages 31987-31998: Synthesis and...
- Energies, Vol. 8, Pages 14407-14426: Life is Short...
- Materials, Vol. 8, Pages 8860-8867: Efficiency Enh...
- An optimized and validated 1H NMR method for the q...
- New approach to the fast screening of plant oil sa...
- Upconversion luminescence tracking of gene deliver...
- Magnetic solid-phase extraction of phthalate ester...
- A handheld laser-induced fluorescence detector for...
- Novel molecularly-imprinted solid-phase microextra...
- Enhancement of Cognitive Functions by Aronia melan...
- Synthetic High-Density Lipoprotein-Like Nanocarrie...
- Tunable Microfibers Suppress Fibrotic Encapsulatio...
- Tissue Engineering for Pediatric Applications
- Delivery of a Cell Patch of Cocultured Endothelial...
- 2015 Lifetime Achievement Award of Tissue Engineer...
- A heterotrimer model of the complete Microprocesso...
- Tunable Microfibers Suppress Fibrotic Encapsulatio...
- Tissue Engineering for Pediatric Applications
- Neonatal Transcutaneous Carbon Dioxide Monitoring—...
- The Role of Mean Platelet Volume in Chronic Obstru...
- Asthma Control Assessment Tools
- Effects of Inspiratory Muscle Training and Calisth...
- Circumstances When Arterial Blood Gas Analysis Can...
- Cough Augmentation in Subjects With Duchenne Muscu...
- Supramolecular recognition control of polyethylene...
- Study of Molecular Adsorption of Cationic Surfacta...
- Development of a novel bacteriophage based biomagn...
- Measuring Global Brain Atrophy with the Brain Volu...
- The Uluzzian technology of Grotta di Fumane and it...
- Editorial Board
- Main Trunk and Division Middle Cerebral Artery Occ...
- JDB, Vol. 3, Pages 177-192: Role of Chondrocytes i...
- Education Sciences, Vol. 5, Pages 413-439: Reading...
- Highly CO2 sensitive extruded fluorescent plastic ...
- Remote Sensing, Vol. 7, Pages 17234-17245: Validat...
- Metals, Vol. 5, Pages 2413-2427: Direct Aqueous Mi...
- Healthcare, Vol. 3, Pages 1271-1283: Psychosocial ...
- Viruses, Vol. 7, Pages 6716-6729: Mechanisms of He...
- Marine Drugs, Vol. 13, Pages 7446-7462: Low-Molecu...
- Information, Vol. 6, Pages 880-894: An Interval-Va...
- Cancers, Vol. 7, Pages 2466-2485: Oncogenic MicroR...
- IJGI, Vol. 4, Pages 2842-2889: Applications of 3D ...
- IJERPH, Vol. 12, Pages 16043-16059: Effectiveness ...
- Religions, Vol. 6, Pages 1411-1432: The Catholic B...
- Veterinary Sciences, Vol. 2, Pages 456-476: Effica...
- Nanomaterials, Vol. 5, Pages 2348-2358: Size Effec...
- Water, Vol. 7, Pages 7066-7077: Reducing Agricultu...
- Nanomaterials, Vol. 5, Pages 2335-2347: Facile and...
-
▼
Δεκ 18
(50)
-
▼
Δεκεμβρίου
(940)
Αναζήτηση αυτού του ιστολογίου
Παρασκευή 18 Δεκεμβρίου 2015
JDB, Vol. 3, Pages 177-192: Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.