Experimental autoimmune encephalomyelitis (EAE) is a CD4+ T cell mediated inflammatory demyelinating disease that is induced in mice by administration of peptides derived from myelin proteins. We developed EAE in SJL mice by administration of PLP139–151 peptide. The effect of treating these mice with 1α,25-Dihydroxyvitamin D3 (vitamin D3), or with monomethyl fumarate (MMF) was then examined. We observed that both vitamin D3 and MMF inhibited and/or prevented EAE in these mice. These findings were corroborated with isolating natural killer (NK) cells from vitamin D3-treated or MMF-treated EAE mice that lysed immature or mature dendritic cells. The results support and extend other findings indicating that an important mechanism of action for drugs used to treat multiple sclerosis (MS) is to enhance NK cell lysis of dendritic cells.
from #Medicine via ola Kala on Inoreader http://ift.tt/1Le1RFo
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 13
(43)
- Toxins, Vol. 7, Pages 4745-4757: A Simple and Rapi...
- Viruses, Vol. 7, Pages 5889-5901: Harnessing the P...
- Toxins, Vol. 7, Pages 4730-4744: Vitamin D3 and Mo...
- Systems, Vol. 3, Pages 287-308: Exploring Tradeoff...
- Membranes, Vol. 5, Pages 702-721: Lipid Diffusion ...
- Marine Drugs, Vol. 13, Pages 6910-6946: Cyanobacti...
- Marine Drugs, Vol. 13, Pages 6884-6909: Marine Dru...
- Machines, Vol. 3, Pages 352-363: Double Lighting M...
- Metals, Vol. 5, Pages 2128-2133: Some Issues in Li...
- Energies, Vol. 8, Pages 12881-12897: An Analysis o...
- Climate, Vol. 3, Pages 876-900: A Survey of the Re...
- Challenges, Vol. 6, Pages 244-257: Human Health Im...
- Biology, Vol. 4, Pages 785-813: Methods for Differ...
- Galaxies, Vol. 3, Pages 192-201: Back to the Green...
- The Role of Different Cycles of Chemotherapy(Capec...
- Cytological Screening for Early Diagnosis of Preca...
- Efficacy and Safety of TC+AVASTIN Versus TC in Pat...
- ADXS 11-001 Vaccination Prior to Robotic Surgery, ...
- Analgesic Effects of Topical Ketamine Mouthwash in...
- SPI-1005 for Prevention and Treatment of Chemother...
- Radiation Therapy With or Without Cetuximab in Tre...
- Antibiotics, Vol. 4, Pages 605-616: Remote Antimic...
- Antibiotics, Vol. 4, Pages 567-604: Co-Selection o...
- Biomolecules, Vol. 5, Pages 3177-3192: Fluorinated...
- Water, Vol. 7, Pages 6483-6495: Effect of Ultrasou...
- Water, Vol. 7, Pages 6467-6482: Obtaining the Ther...
- Behavioral Sciences, Vol. 5, Pages 518-536: Types ...
- Modélisation de l’impact économique d’un dépistage...
- Delayed onset of electromyographic activity of the...
- Acute mountain sickness and obesity
- Reduced expression of miR-503 is associated with p...
- Decreased preoperative serum fibulin-3 levels in c...
- Oxidative stress inhibits growth and induces apopt...
- Cancer stem cells targeting agents – a review
- Focus on biological identity of endothelial progen...
- An extracellular matrixcculture system for induced...
- Prions mediated neurodegenerative disorders
- MiR-16 regulates cell death in Alzheimer’s disease...
- Identification of therapeutic targets of ischemic ...
- Materials, Vol. 8, Pages 7714-7722: A Novel Biodeg...
- Materials, Vol. 8, Pages 7702-7713: Preparation, M...
- Prognostic performance of different lymph node sta...
- A computational chemistry perspective on the curre...
-
▼
Νοε 13
(43)
Αναζήτηση αυτού του ιστολογίου
Παρασκευή 13 Νοεμβρίου 2015
Toxins, Vol. 7, Pages 4730-4744: Vitamin D3 and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.