In our study, we used a mass spectrometry-based metabolomic approach to search for biomarkers that may act as early indicators of spontaneous preterm birth (sPTB). Samples were selected as a nested case-control study from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Cervicovaginal swabs were collected at 20 weeks from women who were originally assessed as being at low risk of sPTB. Samples were analysed using gas chromatography-mass spectrometry (GC-MS). Despite the low amount of biomass (16–23 mg), 112 compounds were detected. Statistical analysis showed no significant correlations with sPTB. Comparison of reported infection and plasma inflammatory markers from early pregnancy showed two inflammatory markers were correlated with reported infection, but no correlation with any compounds in the metabolite profile was observed. We hypothesise that the lack of biomarkers of sPTB in the cervicovaginal fluid metabolome is simply because it lacks such markers in early pregnancy. We propose alternative biofluids be investigated for markers of sPTB. Our results lead us to call for greater scrutiny of previously published metabolomic data relating to biomarkers of sPTB in cervicovaginal fluids, as the use of small, high risk, or late pregnancy cohorts may identify metabolite biomarkers that are irrelevant for predicting risk in normal populations.
from #Medicine via ola Kala on Inoreader http://ift.tt/1HZGWen
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 19
(50)
- The Same but Different: Regulation of Tissue Engin...
- Acute Uncomplicated Diverticulitis: What to Do Unt...
- The Same but Different: Regulation of Tissue Engin...
- ENVIRONMENT AND AGING * TEMPORAL AND SOCIAL ASPECT...
- COMPARATIVE ASSESSMENT OF INDOOR FACILITIES MANAGE...
- ANTICIPATION OF RETIREMENT IN ITALY, UK AND US - E...
- TRAJECTORIES OF DEPRESSIVE SYMPTOMS FOR SPOUSES OF...
- DOES THE OPTION OF CONTINUED WORK LEAD TO A MORE O...
- "TO SEE IT DESTROYED, THAT HURTS": OLDER MINORITIE...
- ANTICIPATED LIFESTYLE CHANGES OVER THE RETIREMENT ...
- CARE RECIPIENT ILLNESS AND CAREGIVING INTENSITY AM...
- ANTICIPATING THE RETIREMENT EXPERIENCE: A CROSS CU...
- TIMING, TRANSITIONS, TRAJECTORIES, AND TURNING POI...
- CLINICAL AND EPIDEMIOLOGY STUDIES: SKELETAL CHANGE...
- DEVELOPING A CHINESE CCRC: AN ETHNOGRAPHIC ACCOUNT
- LIFE COURSE TRAJECTORIES OF FUNCTION: IMPLICATIONS...
- THE ASSOCIATION BETWEEN PERCEIVED NEIGHBORHOOD SAF...
- CORRESPONDENCE OF LATE-LIFE TRAJECTORIES OF FUNCTI...
- FAMILY CAREGIVING FOR ELDERLY PARENTS: DETERMINANT...
- ARE FACTORS ACROSS LIFE ASSOCIATED WITH CHANGES IN...
- Multifunctional, Micropipette-based Method for Inc...
- The Social Dimension of Stress: Experimental Manip...
- Corrigendum to “Electroacupuncture Treatment Impro...
- Streptobacillus moniliformis bacteremia in a rheum...
- Electrophysiology on Isolated Brainstem-spinal Cor...
- Impact of phenolic composition on hepatoprotective...
- Surfactant modulated aggregation induced enhanceme...
- Catalysts, Vol. 5, Pages 1969-1982: Two Carbonylat...
- Phosphoproteomics in the Age of Rapid and Deep Pro...
- Sub-Saharan African migrants living with HIV acqui...
- Intensive care unit surveillance of influenza infe...
- Proton minibeam radiation therapy: Experimental do...
- BrachyView, a novel in-body imaging system for HDR...
- Development of a registration framework to validat...
- Experimental observation of acoustic emissions gen...
- Management of Nonceliac Gluten Sensitivity by Gast...
- Photoluminescence Spectroscopy of Mass-Selected El...
- Flow Field Penetration in Thin Nanoporous Polymer ...
- Energies, Vol. 8, Pages 13194-13210: Cooling Effec...
- Energies, Vol. 8, Pages 13211-13221: Screen-Printe...
- Energies, Vol. 8, Pages 13162-13193: A Survey on D...
- Energies, Vol. 8, Pages 13137-13161: Multi-Objecti...
- IJMS, Vol. 16, Pages 27741-27748: Metabolite Profi...
- Cross-sectional comparison of critically ill pedia...
- Intensive care unit surveillance of influenza infe...
- ECDC publishes 2014 surveillance data on antimicro...
- Epidemiological investigation and case-control stu...
- Sub-Saharan African migrants living with HIV acqui...
- Incidence of invasive meticillin-resistant Staphyl...
- ECDC publishes 2014 surveillance data on antimicro...
-
▼
Νοε 19
(50)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 19 Νοεμβρίου 2015
IJMS, Vol. 16, Pages 27741-27748: Metabolite Profile of Cervicovaginal Fluids from Early Pregnancy Is Not Predictive of Spontaneous Preterm Birth
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.