Background: Metabolic syndrome (MetS) has been identified as a major contributor to the development of cardiovascular disease (CVD). Current recommendations for dietary management of people with MetS involve quantitative and qualitative modifications of food intake, such as high consumption of vegetables, fruits, and whole grain foods. The results from our previous human trials revealed the potential of the dietary components high-oleic acid canola oil (HOCO)-docosahexaenoic acid (DHA) and high molecular weight barley β-glucan individually in managing CVD risk factors. Foods with a combination of HOCO-DHA and barley β-glucan have never been tested for their effects on CVD risk. The objective is to determine the effects of consuming novel foods HOCO-DHA, and barley β-glucan on managing CVD risk factors in people with MetS.Methods/DesignWe are conducting a randomized, single-blind crossover trial with four treatment phases of 28 days each separated by a 4-week washout interval. Participants (n=35) will be provided with weight-maintaining, healthy balanced diet recommendations according to their energy requirements during the intervention periods. Participants will receive muffins and cookies as treatment foods in a random order and will consume at least one meal per day at the research center under supervision. The four treatments include muffins and cookies consisting of (1) all-purpose flour and HOCO-DHA (50 g/day); (2) barley flour (4.36 g/day of β-glucan) and a blend of sunflower oil, safflower oil, and butter as control oil (50 g/day); (3) barley flour (4.36 g/day of β-glucan) and HOCO-DHA (50 g/day; dosage of DHA would be 3 g/day); and (4) all-purpose flour and control oil (50 g/day). At the beginning and end of each phase, we will evaluate anthropometrics; systolic and diastolic blood pressure; blood lipid profile; low-density lipoprotein subfractions and particle size; 10-year Framingham CVD risk score; inflammatory status; and plasma and red blood cell fatty acid profiles, fecal microbiome, and body composition by dual-energy X-ray absorptiometry. Conclusion: Cholesterol synthesis will also be studied, using a stable isotope approach. The proposed study will lead to innovation of novel food products, which may result in improvement in the overall cardiovascular health of humans.Trial registrationClinical trials.gov identifier: NCT02091583. Date of registration: 12 March 2014.
from #Medicine via ola Kala on Inoreader http://ift.tt/1l0I47k
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Οκτωβρίου
(414)
-
▼
Οκτ 30
(40)
- Effect of consuming novel foods consisting high ol...
- Analysis of the Cochrane Review: Interventions for...
- Hyperbaric Oxygen Therapy for the Treatment of Fou...
- Alcohol and Youth in Portugal: An Intervention Thr...
- Haemorrhagic Gingival Hypertrophy: A Striking Pres...
- Pantothenate Kinase Associated Neurodegeneration i...
- Takotsubo Cardiomyopathy: Cause of a Cardiogenic S...
- Auto-Immune Pancreatitis: The Diagnostic Role of I...
- Hypothyroidism Associated to TSH Hormone-Receptor ...
- Periarticular Corticosteroid Injection in the Ther...
- Monoclonal Antibodies for Multiple Sclerosis Treat...
- Current Clinical Indications for Small Bowel Capsu...
- Mediterranean Spotted Fever: Retrospective Review ...
- Acute Ischemic Stroke on Cancer Patients, a Distin...
- Suicidal Behavior among Portuguese Psychiatry Trai...
- Neonatal Morbidity in Term Newborns Born by Electi...
- Translation, Cultural Adaptation and Validation of...
- Quality of Recovery after Anesthesia: Validation o...
- The Importance of Early Referral in Pediatric Acut...
- Characterization and Evolution of Avoidable Admiss...
- Thirdhand Smoke: A Concept to Remember!
- Prophylactic use of the Arabin cervical pessary in...
- Medial temporal lobe atrophy, white matter hyperin...
- Pulsed Direct Current Electrospray: Enabling Syste...
- Sensitive Trimodal Magnetic Resonance Imaging-Surf...
- Enhancement of the Carbon Dots/K2S2O8 Chemilumines...
- CIUSuite: A Quantitative Analysis Package for Coll...
- Imaging of Proteins in Tissue Samples Using Nanosp...
- Modified-Atmospheric Pressure-Matrix Assisted Lase...
- To Your Health: NLM update: Explaining health risk...
- To Your Health: NLM update: Ebola vaccine's initia...
- Tomosynthesis Imaging
- Erratum: “Analytic variance estimates of Swank and...
- Erratum: “Modeling respiratory motion for reducing...
- Optimization of an on-board imaging system for ext...
- Image-derived and arterial blood sampled input fun...
- A round-robin gamma stereotactic radiosurgery dosi...
- A simple clot based assay for detection of procoag...
- Establishment of reference intervals of clinical c...
- Incidence and determinants of neonatal morbidity a...
-
▼
Οκτ 30
(40)
Αναζήτηση αυτού του ιστολογίου
Παρασκευή 30 Οκτωβρίου 2015
Effect of consuming novel foods consisting high oleic canola oil, barley β-glucan, and DHA on cardiovascular disease risk in humans: the CONFIDENCE (Canola Oil and Fibre with DHA Enhanced) study – protocol for a randomized controlled trial
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.